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The way in which gabapentin works is not fully understood.

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It appears to stabilise electrical activity in the brain by affecting the release of various neurotransmitters from nerve cells in the brain and spinal cord.

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A 2010 European Federation of Neurological Societies task force clinical guideline based on available evidence recommended gabapentin as a first-line treatment for diabetic neuropathy and postherpetic neuralgia with its hhest level of evidence; it also recommended gabapentin as a first-line treatment for central pain but with lower evidence.

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Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior.Gabapentin - FDA

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