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The majority of quinolones in clinical use are fluoroquinolones, which have a fluorine atom attached to the central ring system, typiy at the 6-position or C-7 position. Fluoroquinolones are broad-spectrum antibiotics (effective for both gram-negative and gram-positive bacteria) that play an important role in treatment of serious bacterial infections, especially hospital-acquired infections and others in which resistance to older antibacterial classes is suspected.
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