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The CPIC Dosing Guideline update for amitriptyline recommends an alternative drug for CYP2D6 ultrarapid or poor metabolizers and CYP2C19 ultrarapid, rapid or poor metabolizers. Arg368Cys, XR_952745.1:n.2333C The m RNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path.

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If amitriptyline is warranted, consider a 50% dose reduction in CYP2D6 or CYP2C19 poor metabolizers. Pharm GKB sets gene boundaries by expanding the m RNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.Male Enhancement Pill Trial Penis

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