Pharmaceutically abused propranolol

Patent US20060099258 - Propranolol formulations - google.de

The invention relates to a novel method of administering propranolol, a known β-adrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and mraine. 11, 112-120 (1970), report a study in humans has shown that following oral administration of propranolol, peak plasma levels in five subjects given 80 mg oral doses varied seven fold, while levels for 10 mg intravenous doses in the same subjects varied only two fold. The variations in the blood levels as well as the low bioavailability for oral doses has been attributed by various researchers to the extensive metabolism of the drug in the gastrointestinal tract during the absorption process and/or to the effect of the first pass through the liver [Dollery et al., Ann, N. For intravenous administration, the rats were anesthetized and a 1 mg dose of the drug in 0.2 ml isotonic buffer solution (p H 7.2) was injected into each rat through the femoral vein.

The Partial Observer - Performance

Controlled-release propranolol formulations comprise a core comprising a pharmaceutiy acceptable propranolol salt and a sugar sphere; and a coating disposed on the core, the coating comprising about to about of ethylcellulose:polyvinylpyrrolidone....

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Patent US20090238869 - Propranolol formulations - google.ch

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